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  Todays breast cancer 1, early onset (Tag) Articles ...

Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories.
Medline, Cancer genetics [218-219] 58-68, 22-Nov-2017
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.
Medline, Oncotarget [8] 87044-87053, 22-Nov-2017
The role of BRCA status on prognosis in patients with triple-negative breast cancer.
Medline, Oncotarget [8] 87151-87162, 22-Nov-2017
What?s Happening to Your DNA Data?: Genetic Testing Services Abound, but Consumers Opting to Use Them Should Be Aware of the Pitfalls.
Medline, IEEE pulse [8] 10-14, 22-Nov-2017
Phase I/Ib Study of Irinotecan Liposome (Nal-IRI), Fluorouracil, Leucovorin, and Rucaparib in the Treatment of Select Gastrointestinal Metastatic Malignancies Followed by a Phase II Study of First Line Treatment of Selected Patients With Metastatic Adenocarcinoma of the Pancreas With Genomic Markers (Signature) of Homologous Recombination Deficiency (HRD)
ClinicalTrials.gov, , 22-Nov-2017
A Phase 2 Study of Olaparib Monotherapy in Metastatic Breast Cancer Patients With Germline or Somatic Mutations in DNA Repair Genes (Olaparib Expanded)
ClinicalTrials.gov, , 22-Nov-2017
A China Phase I, Open Label, Multi-Center, Dose Escalation and Expansion Study to Investigate the Safety, Pharmacokinetics, and Antitumor Activities of BGB-290 in Subjects With Advanced Solid Tumors
ClinicalTrials.gov, , 21-Nov-2017
A Phase II, Open Label, Randomised, Multi-centre Study to Assess the Safety and Efficacy of Agents Targeting DNA Damage Repair in Combination With Olaparib Versus Olaparib Monotherapy in the Treatment of Metastatic Triple Negative Breast Cancer Patients Stratified by Alterations in Homologous Recombinant Repair (HRR)-Related Genes (Including BRCA1/2) (VIOLETTE).
ClinicalTrials.gov, , 20-Nov-2017

  This Weeks breast cancer 1, early onset (Tag) Articles ...

The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells.
Medline, Breast cancer research : BCR [19] 122, 19-Nov-2017
Germline Genetic Features of Young Individuals with Colorectal Cancer.
Medline, Gastroenterology, 19-Nov-2017
Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing.
Medline, Genome research, 19-Nov-2017
Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer.
Medline, Scientific reports [7] 15742, 19-Nov-2017
The molecular basis of cytotoxicity of α-spinasterol from Ganoderma Resinaceum: induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines.
Medline, Journal of cellular biochemistry, 18-Nov-2017
Current status of poly(ADP-ribose) polymerase inhibitors and future directions.
Medline, OncoTargets and therapy [10] 5195-5208, 17-Nov-2017
The Potential Contribution of BRCA Mutations to Early Onset and Familial Breast Cancer in Uzbekistan.
Medline, Central Asian journal of global health [5] 228, 17-Nov-2017
Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer.
Medline, Oncotarget [8] 81803-81812, 17-Nov-2017
A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors.
Medline, Clinical cancer research : an official journal of the American Association for Cancer Research, 17-Nov-2017
Targeting the MYCN-PARP-DNA Damage Response Pathway inNeuroendocrine Prostate Cancer.
Medline, Clinical cancer research : an official journal of the American Association for Cancer Research, 17-Nov-2017
Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancer.
Medline, Oncotarget [8] 83063-83074, 17-Nov-2017
Titanium Activates the DNA Damage Response Pathway in Oral Epithelial Cells: A Pilot Study.
Medline, The International journal of oral & maxillofacial implants [32] 1413-1420, 17-Nov-2017
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